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《Chinese Journal of Contemporary Neurology and Neurosurgery》 2016-11
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Effect of panax notoginseng saponins on efficacy and hemorrhagic transformation of rt-PA intravenous thrombolysis in patients with acute ischemic stroke

LI Chun-sheng;GAO Yan-hong;CHANG Jian-jun;LI Hao;Department of Neurology, Xinyang Central Hospital;  
Objective To study the effect of panax notoginseng saponins(PNS) on the efficacy andhemorrhagic transformation(HT) of recombinant tissue- type plasminogen activator(rt- PA) intravenousthrombolysis in patients with acute ischemic stroke. Methods A total of 200 patients with early acuteischemic stroke(the length of time between attack and hospital admission 4.50 h) were divided into2 groups according to random number table method: treatment group(N = 100) and control group(N = 100).The control group was treated with routine rt- PA intravenous thrombolysis treatment, and the treatmentgroup was treated with rt-PA intravenous thrombolysis plus PNS injection. The ischemia-reperfusion injuryindex [malondialdehyde(MDA) and superoxide dismutase(SOD)], hemorrhagic transformation predictionindex [matrix metalloproteinase- 9(MMP- 9) and fibronectin(FN)] and nerve function index [NationalInstitutes of Health Stroke Scale(NIHSS) and Barthel Index(BI)] were measured and compared beforetreatment, 24 h after thrombolysis and 14 d after thrombolysis. Adverse drug reactions and hemorrhagictransformation rate were observed 14 d after thrombolysis, and the prognosis(mortality and BI) wasevaluated 12 months after thrombolysis. Results Compared with control group, serum SOD(P = 0.000)and BI(P = 0.000) in treatment group were significantly higher, while serum MDA(P = 0.001), MMP-9(P =0.001), plasma FN(P = 0.000) and NIHSS score(P = 0.006) were significantly lower. In treatment group,24 h after rt-PA intravenous thrombolysis plus PNS injection, serum MDA(P = 0.000), MMP-9(P = 0.000)and BI(P = 0.000) were significantly increased, while NIHSS score(P = 0.000) was significantly decreased;14 d after treatment, serum MDA(P = 0.000) and MMP-9(P = 0.000) were decreased, serum SOD(P =0.000) and BI(P = 0.000) were continuously increased, plasma FN(P = 0.000) and NIHSS score(P = 0.000)were continuously decreased. On the 14 th day after thrombolysis, hemorrhagic transformation rate of treatment group was lower than that of control group [9 cases(9%) vs 19 cases(19%); χ2= 4.153, P =0.042]. There was no significant difference in the incidence of adverse drug reactions between 2 groups[14 cases(14%) vs 11 cases(11%); χ2= 0.411, P = 0.521]. Twelve months after thrombolysis, there were5 cases of death(5%) in control group and one case(1%) of death in treatment group. There was no significant difference in the incidence of mortality between 2 groups(χ2= 1.546, P = 0.241). The BI of treatment group was significantly higher than that of control group(88.51 ± 11.49 vs 84.47 ± 9.83; t = 2.451,P = 0.015). Conclusions PNS reduces ischemia-reperfusion injury after rt-PA intravenous thrombolysis in patients with acute ischemic stroke. It can reduce the rate of hemorrhagic transformation after rt- PA intravenous thrombolysis and improve the prognosis with good safety.
【CateGory Index】: R743.3
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Chinese Journal Full-text Database 1 Hits
1 YOU Xue-mei;HOU You-rong;DI Hai-li;MENG Jun-peng;Department of Internal Medicine,the Fourth People's Hospital of Shaanxi Province;;Effect of Antiplatelet Drug History on Efficacy of Intravenous Thrombolysis in Treatment of Patients with Acute Ischemic Stroke[J];解放军医药杂志;2017-10
Chinese Journal Full-text Database 3 Hits
1 Tian Hong;Liu Lei;Hao Lei;Zang Qiaoli;Zhu Chuan;Department of Cerebrovascular Disease Center,No.324 Military Hospital of People′s Liberation Army;;The clinical characteristics analysis of 48 cases with hemorrhagic transformation after acute cerebral infarction[J];重庆医学;2015-02
2 ZHANG Lanke;WEI Suzhi;ZHANG Yan;ZUO Jianghua;YANG Yunxia;Department of Clinical Laboratories,Xingtai People's Hospital;;Serum biomarkers of hemorrhagic transformation after acute ischemic stroke[J];国际脑血管病杂志;2014-06
3 Jiang Guohui,Wang Zijun,Li Guangqin,et alThe Central Hospital of Fuling(Chongqing 400016);Study of Panax Notoginseng Saponins on Thrombolysis-induced Hemorrhagic Transformation in Rats with Thrombusoccluded Cerebral Ischemia[J];中西医结合心脑血管病杂志;2009-09
Chinese Journal Full-text Database 8 Hits
1 WAN Ting;XU Qian-yu;XU Zun-bao;Panyu District Central Hospital;;Analysis on current status and high risk factors of secondary cerebral hemorrhage after cerebral infarction intravenous thrombolysis[J];护理实践与研究;2017-17
2 ZHANG Yi;CHEN Ke;LI Min;Department of Acupuncture and Moxibustion,Wuhan Traditional Chinese and Western Medicine Hospital;;Effects of 70 pearl flavor pill associating with acupuncture on nerve function in acute cerebral infarction patients[J];中国生化药物杂志;2017-07
3 ZHANG Bai-chang;ZENG Guan-hong;HUANG Ming-zhong;Department of Radiology,Dongguan Qishi Hospital;;Imaging Features of CT and MRI in Hemorrhagic Transformation of Cerebral Infarction[J];中国CT和MRI杂志;2017-06
4 ZHANG Guo-sheng;CT Room, Hebi City People's Hospital;;Analysis on Multi Slice Spiral CT Features and Related Risk Factors of Hemorrhagic Transformation after Cerebral Infarction[J];中国CT和MRI杂志;2017-05
5 ZHANG Yujia;WU Ping;XU Ping;YANG Ming;Department of Rehabilitation, First People's Hospital of Shuangliu District,Chengdu;;Effects of panax notoginseng saponins on ischemia reperfusion injury and hemorrhagic transformation after recombinant tissue plasminogen activator intravenous thrombolysis in patients with acute cerebral infarction[J];临床与病理杂志;2017-02
6 ZHANG Xiao-feng;Department of Neurology,Chang'an Hospital of Xi'an;;Risk Factors of Hemorrhagic Transformation in Middle Aged and Elderly Patients with Acute Cerebral Infarction[J];实用心脑肺血管病杂志;2017-02
7 LI Chun-sheng;GAO Yan-hong;CHANG Jian-jun;LI Hao;Department of Neurology, Xinyang Central Hospital;;Effect of panax notoginseng saponins on efficacy and hemorrhagic transformation of rt-PA intravenous thrombolysis in patients with acute ischemic stroke[J];中国现代神经疾病杂志;2016-11
8 Zhang Xiaohong;Department of Neurology,Affiliated Central Hospital of Shenyang Medical College;;Risk factors of hemorrhagic transformation in fibrinolytic treatment of acute ischemic stroke[J];中华保健医学杂志;2016-05
Chinese Journal Full-text Database 9 Hits
1 Huang Qiang;Ma Qingfeng;Song Haiqing;Wu Jian;Department of Neurology,Xuanwu Hospital,Capital Medical University;Department of Neurology,Beijing Tsinghua Changgung Hospital,Medical Center,Tsinghua University;;Association between glucose parameters and outcome measures in acute ischemic stroke with intravenous thrombolytic treatment[J];首都医科大学学报;2017-01
2 Wang Qi;Wang Manxia;Zhang Shuaijie;Department of Neurology,the Second Hospital of Lanzhou University;;Efficacy of using statins before thrombolysis for intravenous thrombolysis in ischemic stroke:a systematic review[J];中国脑血管病杂志;2016-12
3 LI Chun-sheng;GAO Yan-hong;CHANG Jian-jun;LI Hao;Department of Neurology, Xinyang Central Hospital;;Effect of panax notoginseng saponins on efficacy and hemorrhagic transformation of rt-PA intravenous thrombolysis in patients with acute ischemic stroke[J];中国现代神经疾病杂志;2016-11
4 LU Rui-tao;TONG Xiu-qing;WANG Shu-fang;Department of Neurology,Affiliated Hospital of Inner Mongolia Medical University;;Analysis of Etiological and Risk Factors of Different TOAST Types in Young Patients with Cerebral Ischemic Stroke[J];临床误诊误治;2016-11
5 ZHANG Min-min;WU Xiong-feng;CHEN Lei;JIANG Yi;ZHU Xuan;ZHANG Yong-wei;WU Tao;DENG Ben-qiang;Stroke Center,Changhai Hospital,Second Military Medical University;;Influence of time management on intravenous thrombolysis outcome in acute ischemic stroke[J];第二军医大学学报;2016-10
6 LI Jing;TIAN Ting;SHI Zheng-hong;FENG Bin;ZHAO Li-li;Department of Neurology,Second Hospital of Lanzhou University;;Clinical distribution characteristics and analysis on risk factors of carotid vulnerable plaque in patients with acute ischemic stroke[J];解放军医学杂志;2016-09
7 Zhang Runhua;Liu Gaifen;Pan Yuesong;Jiang Yong;Wang Yilong;Wang Yongjun;Neurology Center,Beijing Tiantan Hospital Affiliated to Capital Medical University;;Association between hemoglobin concentration and stroke severity on admission in ischemic stroke without diabetes[J];中国综合临床;2016-09
8 Zhang Ping;Zhang Yongwei;Wu Tao;Chen Lei;Jiang Yi;Deng Benqiang;Cerebrovascular Disease Center,Changhai Hospital,the Second Military Medical University;;Analysis of influencing factors of the prognosis of intravenous thrombolysis combined with endovascular interventional therapy in patients with acute moderate to severe cerebral infarction[J];中国脑血管病杂志;2016-07
9 YUE Ran;LIU Xingde;ZHANG Haitao;ZHANG Chao;LUO Huilan;CHEN Yongsheng;Department of Cardiology,Air Force General Hospital;;Study of relationship of positive acceleration tolerance and plasma C-reactive protein and endothelin-1 levels in swines with different coronary artery stenosis[J];空军医学杂志;2016-03
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Chen Li,Qin Xinyue(Department of Neurology,First Affiliated Hospital,Chongqing Medical University,Chongqing,400016,China);Analysis related factors of hemorrhagic transformation after ischemic stroke[J];第三军医大学学报;2012-21
2 Zhang Yongbo, Li Li Shanxi Medical University(Taiyuan 030001);Effect of Astragalus March Notoginseng on the Expression of TIMP-1[J];中西医结合心脑血管病杂志;2007-04
3 WANG Wen-an, ZHOU Yong-wei, CHEN Jie, WANG Geng-fa, CHEN Xin-hua (Department of Neurology, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China);Effect of Panax notoginseng saponins on MMP-9 expression after focal cerebral ischemia-reperfusion[J];上海第二医科大学学报;2004-09
4 Mao Chun, Deng Xiaohong, Zhang Suming. Department of Neurology, Xianfan Central Hospital, Xiangfan;Thrombolytic therapy with urokinase by using an modified thromboembolic stroke model in rats[J];卒中与神经疾病;2003-01
5 CHANG Li Ying, ZHANG Su Ming, ZHANG Xin Jiang, et al. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430030,China;Effect of Intravenous Urokinase on Acute Cerebral Infarction after Middle Cerebral Artery Occlusion Embolized by Autologous Blood Clots in Rat[J];中国临床神经科学;2002-03
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