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Effects of Combination of Aspirin and Isorhynchophylline on Antiplatelet Aggregation

ZHANG Wei;ZHOU Yuanfen;HAO Xing;SHI Jingshan;XIE Xiaolong;Department of Pharmacology of Zunyi Medical College and Key Laboratory of Basic Pharmacology of Guizhou Province;Department Cardiovascular of Affiliated Hospital of Zunyi Medical College;  
OBJECTIVE To investigate the effects of the combination of aspirin(ASP) and isorhynchophylline(Iso) on rabbit platelet aggregation in vitro.METHODS The rabbit platelet aggregation induced by collagen(Col),thrombin(Thr),and adenosine diphosphate(ADP) in vitro was determined by Born method,respectively.RESULTS Combination of ASP and Iso concentration-dependently inhibited platelet aggregation induced by Col(50mg·L-1),Thr(3U·m L-1) and ADP(15μmol·L-1).CONCLUSION Combination of ASP and Isohas the effect of synergistic inhibition on platelet aggregation.
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