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《Modern Medical Imagelogy》 2001-01
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A Radiographic Study of bBMP/Collagen/Coral Composited Bone Substitute in Repairing of Bone Defect of Femoral Head

Xu Xiaoliang 1 Tong Zhiqin 2 Wang Kunzheng 2 et,al 1 Department of Orthopedics,The Affiliated 9st Hospital,Second Medical University Shanghai 200011 2 Department of Orthopedics,The 2nd Hospital of Xi′an Jiaotong University, 710004  
Purpose:To evaluate the effectiveness of bBMP/collagen/coral composited bone substitute in treatment of avascular necrosis of the femoral head(ANFH).Materials and Methods:Canine bone defect of bilateral femoral head was established,They were devided into 4 groups:I.composited bone substitute group(n=5),Ⅱ.muscle pedicle bone group(n=5),Ⅲ.simple coral group(n=4),Ⅳ.control group:contralateral hip(n=14).Roentgenography,Scintigraphy,MRI,CT were examined and studied at various time.Results:(1)Scintigraphic changes:In group I,static bone image showed increased radionuclide uptake,but blood-flow and blood-pool image didn′t show at 6th and 12th week.(2)MRI changes:In group I,T 1WI and T 2WI showed a low signal intensity in the bone defect at 10th week;In group Ⅳ,T 1WI and T 2WI showed a high signal intensity at the center and a low signal intensity at the wall of bone defect (3)Roentgenographic and CT changes:At 14~16th week,in group I,the coral was absorbed,most of the bone defects were closed completely;In the rest groups,part of each bone defect was remained;I group Ⅳ,cystic sclerosis was formed.Conclusion:The composited bone substitue possesses a superior osteoinductivity and osteoconductivity in the repairing process of bone defect of femoral head,but it can′t improve the revascularization of ANFH.
【CateGory Index】: R816.8
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1 Xu Xiaoliang,Tong zhi qin,Wang Kunzhen et al.Department of Orthopedics,The Second Affiliated Hospital of Xi'an Medical University,Xi'an,710004.;Experimental Study of bBMP/Collagen/Coral Composited Bone Substitute in Repairing of Bone Defect of Femoral Head[J];The Journal of Bone and Joint Injury;2000-03
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