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《Modern Medical Imageology》 2018-04
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Application of Diffusion Kurtosis Imaging in T2DM Patients' Cognitive Impairment

Zhang Haidu;Liu Guorui;Zheng Wenbing;Kong Lingmei;Department of Radiology,the Second Affiliated of Medical College of Shantou University,Shantou;  
Purpose: To explore the the value of Diffusion kurtosis imaging( DKI) in type 2 diabetes mellitus( T2DM). Materials and Methods: DKl were applied to 40 patients with T2DM and 40 patients without T2DM to be the control group,and get their MMSE scores. Measure the value of DKI indexes in bilateral ROI of T2DM and control group,compare the mean values of DKI indexes between the two groups,and correlate the mean value of DKI indexes with MMSE scores. Results: Compared with control group,the mean MK、AK、RK values of most of ROI in T2DM group decrease( P 0. 05). The mean FA value of right frontal lobe,right hippocampal,center of right hemi oval in T2DM group decrease,but the mean AD value increase. The mean RD、MD value of right hippocampal,pad of corpus callosum in T2DM group increase. The mean MK、AK、RK of parts of ROI in T2DM group were positive correlated with MMSE scores,but the mean AD of them were negative correlated with MMSE scores. The mean RD、MD value of right hippocampal,pad of corpus callosum were negative correlated with MMSE scores. Conclusion: DKI can not only provide traditional dispersion index,but also provide additional kurtosis index. It can be used to detect the ultrastructure of brain in patients with T2DM,provide objective index for the evaluation of the patients' cognitive impairment.
【Fund】: 广东省医学科学技术研究基金项目(项目编号:A2015541);; 汕头市科技计划项目:汕头市财教[2014]242号项目编号60
【CateGory Index】: R445.2;R587.1
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