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《Modern Traditional Chinese Medicine》 2007-01
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The Effect of Qiang Xin Fu Mai Granules on Animal Brady Arrhythmia Model

Wan Sujun Liu Ruxiu Zheng Jun Chen Chao Huang Shijing,(Guang'anmen Hospital of China's Traditional Chinese Medicine Science Institute,Bejing,100053)  
Objective To study the effect of Qiang Xin Fu Mai granules on the model and its mechanism on the basis of the establishing of animal brady arrhythmia model.Methods Mouse bradycardia model was made by Yi Bo Ding.Rabbit brady arrhythmia model due to acute sinoatrial node damage was made by overlaying 30% formaldehyde on the surface of sinoatrial node area.The effects of Qiang Xin Fu Mai granules on the above-mentioned two types of arrhythmia were observed,and the model control group and the positive therapeutic control group were established.Results Qiang Xin Fu Mai granules obviously improved the condition of mouse bradycardia caused by Yi Bo Ding.And there was a significant difference compared with the control group.It had protective and repairment-improving effects on the rabbit's acute sinoatrial node damage caused by formaldehyde,and obviously improved the heart rate.30min after the administration of medicine to duodenum,the mean heart rate had a significant improvement compared with the control group,and maintained to 120min of the observation period.Conclusion Qiang Xin Fu Mai granules has an obvious counteraction to the mouse brady arrhythmia caused by Yi Bo Ding,and can improve the heart rate of rabbit brady arrhythmia due to acute sinoatrial node damage caused by formaldehyde.
【Fund】: 国家中医药管理局基金(02-03LP53)
【CateGory Index】: R285.5
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