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《Modern Traditional Chinese Medicine》 2011-01
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Xiao Ke Tong Bi Granules:Its Effects on the Expression of VEGF during Pulpation Repairment in DM Rats with Neural Ischemia

Xie Bo1 Zhang Xiaoke2(1.Postgraduate of Grade 2008,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712046; 2.Shaanxi University of Chinese Medicine,Xianyang,Shanxi,712046)  
Objective To investigate the effects of Xiao Ke Tong Bi granules on the expression of VEGF during pulpation repairment in DM rats with neural ischemia.Methods DM rats model was induced with STZ.The femoral arteies and veins of the model rats were ligated to induce unilateral limb ischemia.Intragastric administration was used with different doses of Xiao Ke Tong Bi granules.Cilostazol was administered as comparison.The changes of VEGF of the rats' nervi ischiadicus were observed 8 weeks later.Results All doses of Xiao Ke Tong Bi granules could improve the expression of VEGF of DPN rats' nervi ischiadicus.And the difference has statistical significance compared with Cilostazol(P0.05).Conclusion Xiao Ke Tong Bi granules can ease or improve diabetic peripheral nerve injury,and its mechanism is probably related with its regulation of VEGF expression
【Fund】: 陕西省教育厅专项科研计划(09JK412);; 咸阳市科技计划项目[XK0817-2(7)]
【CateGory Index】: R285.5
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【Citations】
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【Co-citations】
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1 XUE Lei.Huaihe Hospital Affiliated to Henan University,Kaifeng 475000,China;Prostaglandin combined with methylcobalamin in treatment of diabetic peripheral neuropathy[J];Clinical Medicine;2010-12
2 CHEN Kai-dong LU Hui-lun ZHUANG Xue-fen (Medical Department of Buji Hospital in Longgang District of Shenzhen City,Shenzhen 518112,China);Observation of therapeutic effects of the combination of Nimotop and Mecobalamine on diabetic peripheral neuropathies[J];Journal of Guangdong Medical College;2007-06
3 HUANG Wen-sen (Department of Internal Medicine,Higher Professional Medical School in Quanzhou Quzhou 362000,China);Combined treatment with buflomedil and hydrochloride epalrestat for diabetic peripheral neuropathy[J];Journal of Hainan Medical College;2009-12
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1 Zhang Shuping , Lu Ju ming , Pan Changyu ,et al. Department of Endocrinology , General Hospital of P L A, Beijing ,100853;Effect of methylcobala min on peripheral neuropathy in diabetic rats[J];CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM;1998-02
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