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《Modern Traditional Chinese Medicine》 2011-01
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Inhibitory Effect of Jujube Kernel Oil on Mice Bearing S180 Sarcoma

Du Yuandong1 Hu Rui2 Liu Jiping2 1.Postgraduate of Grade 2009,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712046; 2.Teaching and Research Section of Pharmacology,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712046)  
Objective To observe the effects of jujube kernel oil on thymus index,spleen index and tumor-inhibition rate of S180-bearing mice,and to investigate the inhibitory effect of jujube kernel oil on S180 sarcoma.Methods Healthy mice inoculated with s180 sarcoma cells were randomized into 5 groups 24h after the inoculation.They are: high dose jujube kernel oil group,medium dose jujube kernel oil group,low dose jujube kernel oil group(the doses were 3mL/kg,1.2mL/kg and 0.5mL/kg respectively),positive control group and model control group.The rats were killed by dislocating the cervical vertebra after 14 days continuous administration.Thymus index,spleen index and tumor-inhibition rate of each group were determined.Two-tailed t-test was done between the groups.Results The tumor-inhibition rate of high dose jujube kernel oil on S180 bearing mice was 58.21%(P0.05),and spleen index and thymus index were increased in the mean time.The effect of cyclophosphamide was consistent with the literature reports.Conclusion Jujube kernel oil has certain inhibitory effect on the growth of sarcoma in S180 bearing mice,and can obviously increase the spleen and thymus indexes of the mice.
【CateGory Index】: R285.5
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