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Expressions of Laminin and Type Ⅳ Collagen and its Correlation with Lung Cancer Metastasis

Hu Xuewen; Situ Rui (Aedical of Ji-Nan University, Guangzhou 510632)  
(Purpose) To explore the relationship between expressons of laminin(LN) and type Ⅳ collagn in lung cancer tissues and lung cancer metastasis. (Methods) LN and type Ⅳ collagen in 49 cases of lung cancer and 20 cases of lymph node with metastasis of lung tumor cells were both studied by immunohistochemistry method (labelled streptavidin biotin method ). (Results ) The results showed a close relation between the expressions of LN and of collagen Ⅳ in lung cancer tissues, P<0.005. The total positive rates of LN and collagen Ⅳ were 73. 47% and 71. 43% respectively, The posltive basement membrance(BM) like substance formed by L N and type Ⅳ collagen presented in 4 types, continual line, uncontinual line, prece, and absent in tissues of lung cancer. The metastastic rate of the group with continual BM like substance was remarkably lower than that with uncontinual one, p<0.05, It also had been noticed the better the differentiation,the more complete the BM like substance present in these specimen, and they were more complete in stage I than in others, P=0. 01 9. (Conclusions) These results suggested that the present methods of the BM like substance in lung cancer tissues were closely correlated with lung cancer metastasis.
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