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The Study about Chemosensitivity of Non-Small Cell Lung Cancer and its Clinic Biological Behaviors

Xu Meng; Li Jinghan (Nanfang Hospital of First Military Medical University, Guagzhou 510515)  
(Purpose) To research intrinsic sensitivity of non-small cell lung cancer (NSCLC) to chemotherapy and affection factors of clinic biological behaviors of NSCLC. (Methods) We detected 31 NSCLC samples by MTT colorimetric assay about chemosensitivity to 9 anticartinogens. Each drug had 3 dose dilutions. The result was analysed by the inhibition rate of each drug with one-way ANON.(Results) The chemosensitivity of 31 lung cancer Sampes was as below: Vinorelbine bitartate 83. 87%, Vincristine 77- 42%, Mitomycin 74. 19%, Adriamycin 69. 72%, Carboplatin 69. 72%, Cisplatin 61. 29%, Etoposide 58. 06%, Methotrexate 22. 58%, 5-Fluorouracil 19. 35%. The inhibition rate was abolutely increasing with dilution increasng of 9 anticaednogensi In squamous carinoma the inhibition rate of Etoposide and Adriamycin was obviously moe than that in adenocarinoma. In poor djfferntiation NSCLC the inhihition rate of Etopeide and Cisplatin was obviously more than that in moderate and high differentation NSCLC. (Conclusions) In vitro chemosenaitivity assay was affected by multiple tesl lactors. There were correlative between chemosensitivity of NSCLC and its degree of histopathologial and differentiation.
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