The Tumor Inhibitory Effect of Bee Production Complex Preparation“HAO-LI” in Tumor-Bearing Mice
YANG Yao-qin 1,LU Pei-xin 2,LIU Dong-sheng 3,et al.(1.Shanghai Cancer Institute,Shanghai 200032,China; 2.Qidong Liver Cancer Institute,Qidong 226200,China; 3.Shanghai Haoli High Tech Health Production Co.Ltd.,Shanghai 201900,China)
urpose〕To investigate the tumor inhibitory effect of bee production complex preparation “HAO LI” in tumor bearing mice.〔Methods〕Thirty cases of male kunming species mice were radomized into three groups. The mice in experiment group Ⅰ were gived HAO LI by gastric filling method for two weeks and were subcutaneously inoculated with H 22 cells and were then sacrificed after another two weeks' feeding of HAO LI.Normal saline was administered to mice in experiment group Ⅱ by gastric filling for two weeks and it was changed to HAO LI administra- tion for another 2 weeks following the inoculation of H 22 cells.Normal saline was administered to the control group before and after inoculation of H 22 cells. All mice were sacrificed at the same day in order to strip the entire tumor and weight it, to measure tumor's diameter and calculate tumor inhibitory rate and to send for detect in pathologic examination.〔Results〕The tumor weight(x±s)in experiment group Ⅰ,Ⅱ and control group were (0.532±0.397)g,(0.788±0.508)g,(1.495±0.430)g,respectively.There was significant difference between experiment groups and control group(P0.01).The tumor inhibitory rate in the experiment group Ⅰ,Ⅱ were 64.42%,47.29%,respectively.The degrees of tumor necrosis in the experiment groups were more severe than that in the control group.〔Conclusion〕 The bee production complex preparation “HAO LI” can effectively prevent and inhibit tumor growth and metastasis in tumor bearing mice.