Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Oncology》 2006-01
Add to Favorite Get Latest Update

A Clinical Study on Megestrol Improving Chemotherapy Tolerance in Patients with Cancer

YANG Xin-mei1,WANG Xiao-jia2 (1. The First Hospital of Jiaxing, Jiaxing 314000,China; 2. Zhejiang Cancer Hospital, Hangzhou 310022,China)  
[Purpose] To investigate the impact of megestrol on chemotherapy tolerance in patients with cancer. [Methods] Eight-one cases with non-small cell lung cancer(NSCLC) and 39 cases with breast cancer were divided into two groups(each 60 cases), megestrol group with chemotherapy plus megestrol(480mg/d) and control group with chemotherapy alone. The appetite, weight, body performance, bone marrow function and immune function during treatment were observed. [Results] More patients treated with megestrol had good appetite than control group, 65.0% vs 25.0%, P0.01. In megestrol group, the number of male patients were similar to female in appetite and weight gain, but the time of weight gain up to 2.5kg for the female was significantly shorter than that for the male(14.7days vs 36.6days),P0.05. More patients with megestrol reserved the normal bone marrow function(30.0% vs 10.0%,P=0.000) and immune function(61.9% vs 39.5%,P=0.045) than control during the period of chemotherapy, and the 3~4 grade leukopenia was lower(28.3% vs 48.3%,P=0.049) and the KPS increased markedly (P=0.000) in megestrol group but dereased in control group(P=0.049). The overall adverse events were little in megestrol group. [Conclusion] Megestrol can increase the appetite and weight, improve the body performance, reserve bone marrow function and immune function, and increase the tolerance in cancer patients during chemotherapy. Subject
【CateGory Index】: R730.53
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved