Paclitaxel Combined with 5-fluorouracil and Cisplatin in the Treatment of 58 Cases with Advanced Gastric Cancer
YING Jie-er,ZHONG Hai-jun,DONG Yong(Zhejiang Cancer Hospital,Hangzhou 310022,China)
[Purpose] To evaluate the efficacy and toxicity of paclitaxel(PTX)combined with 5-fluorouracil(5-Fu)and cisplatin(DDP)regimen(PCF regimen)in patients with advanced gastric cancer.[Methods] Fifty-eight cases with advanced gastric cancer were treated with PCF regimen:PTX 150mg/m2 3h d1,5-Fu 500mg/m2 d1～5 or 750mg/m2 d1～3,DDP 15mg/m2 d1～5 or 30mg/m2 d1～3 every 21～28 days.Response and toxicity were evaluated according to RESCIST standard after 2 courses.[Results] Fifty-seven cases were available for response evaluation.In the initial treatment group the response rate was 42.9% with CR,0;PR,15;SD,17;PD,3;and the time to tumor progression(TTP)was 6.0 months.In the retreatment group the response rate was 13.6% with CR,0;PR,3;SD,16;PD,3;and the TTP was 3.2 months.The main toxicities were bone marrow suppression,nausea /vomiting and alopecia.[Conclusion]PCF regimen has an assured response for advanced gastric cancer with tolerable toxicity,especially for initial treatment.