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Re-treatment of Vaginal Recurrence Following Treatment for Cervical Cancer in 193 Cases

WANG Xiang-e1, GAO Yong-tao2, CAI Shu-mo1, et al. (1.Cancer Hospital of Fudan University, Shanghai 200032, China; 2.The International Peace Maternity & Child Health Hospital of China Welfare Institute, Shanghai 200030, China)  
[Purpose] To assess the treatment effect for vaginal recurrence following initial surgical or radiation therapy for cervical cancer. [Methods] One hundred and ninety-three cases of cervical cancer with vaginal recurrence after initial surgical or radiation therapy in Cancer Hospital, Fudan University from Jul. 1972 to Jul. 1992 were retrospectively analyzed. Reradiation-based concurrent chemotherapy were carried out. [Results] The 2-, 3-, 5-year survival rate in recurrence after operation was 65.8%,56.9% and 44.1%; and in recurrence after radiation was 50.0%, 40.6% and 30.2% respectively, with significant difference between the two groups (P0.05). The local control rate in tumor volume 4cm and ≥4cm was 89.1% and 76.0% respectively in the group of recurrence after operation (P0.05); and in the group of recurrence after radiation, was 80.0% and 25.0% respectively (P0.01). The radiation complications were higher in group with initial radiation than that initial with surgery. The rate of radiation cystitis (hematuria), middle and serious rectal radiotoxicity in group with initial radiation was 13.1%, 15.7% and 14.9%, respectively. There was significant difference in local control and 5-year survival rate of re-radiation for early and late recurrence in group with initial radiation. (P0.01). [Conclusion] It is valuable to radiation again for cervical cancer with vaginal recurrence. Individualized treatment should be carried out to alleviate the radiation complications.
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