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The Efficacy of IMRT Combined with Chemotherapy at Various Time Points on Parotid Function in Patients with Nasopharyngeal Carcinoma

ZHANG Fan,YANG Lin,HONG Hao,et al.(The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)  
[Purpose] To investigate the effect of IMRT combined with chemotherapy at various time points on parotid function in patients with nasopharyngeal carcinoma.[Methods] Thirty-nine cases with nasopharyngeal squamous carcinoma were randomly divided into IMRT alone group,chemoradiotherapy group 1(chemotherapy begun at the first week of radiotherapy)and chemoradiotherapy group 2(chemotherapy begun at the third week of radiotherapy);there were 13 patients in each group.All patients were treated with IMRT.Chemotherapy agents were cisplatin and paclitaxel.[Results] Compared with IMRT alone group,the local tumor control rate was higher in chemoradiotherapy group,but the injury of parotid gland was more serious,especially in chemoradiotherapy group 1.[Conclusions] Chemotherapy plus radiotherapy at various time points can improve therapeutic efficacy and reduce injury of parotid gland in patients with nasopharyngeal carcinoma.
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