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《Journal of Chinese Oncology》 2012-01
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The Expression of RECK,VEGF and MVD in Non-small Cell Lung Cancer and Their Correlation

WANG Chong-chong,QIN Xue-jin,MA Qiang,et al.(The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)  
[Purpose] To investigate the expression of RECK,VEGF and MVD in non-small cell lung cancer(NSCLC) and their correlation.[Methods] The expression of RECK,VEGF and MVD in 80 NSCLC tissues and 20 adjacent tissues was detected by immunohistochemical SP method.[Results] RECK-expression in cancer tissues was higher than that in adjacent tissues(26.25% vs 85.00%,P= 0.0001),VEGF-expression and MVD were lower than those in adjacent tissues(68.75% vs 35.00%,P= 0.005;20.94±8.76 vs 10.57±4.24,P=0.0001).RECK-expression decreased in squamous cell carcinomas and in medium/low differentiation tumors.VEGF-expression increased in adenocarcinoma.MVD value increased in patients less than 60 years old.VEGF-expression was positively correlated with MVD.RECK-expression was negatively correlated with MVD.Multivariable Logisitic regression analysis showed that low expression of RECK protein was poor prognosis factor.[Conclusion] The expression of RECK,VEGF and MVD is certainly correlated to NSCLC.Low expression of RECK is a poor prognosis factor.
【Fund】: 安徽省教育厅2010年省级自然科学研究重点项目资助(KJ2010A166)
【CateGory Index】: R734.2
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【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHANG Yong, ZHENG Qi-chang, LU Xin, ZHANG Jing-hui, TIAN Yuan Department of General Surgery, Xiehe Hospital, Wuhan 430030,P.R.China;Expression of transformation suppression gene RECK in gastric carcinoma and its clinic significiance[J];Journal of Qilu Oncology;2005-02
2 XIONG Zheng wen, XU Chang fu, LI Hong wei, et al. The 251st Hospital of PLA, Zhangjiak ou, Hebei 075000, China;Comparison of CD_(34) , CD_(31) and F_(VIII) served as labels to show the microvascular density in non-small cell lung cancer[J];Chinese Journal of Thoracic and Cardiovascular Surgery;2003-04
3 Zhang Peitong, Pei Yin gxia, Piao Bingkui, et al. Tumor Department, Guanganmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053;Clinical observation on the adhesion molecule expression and functional study of platelets in cancer patients[J];CHINESE JOURNAL OF ONCOLOGY;1998-03
4 ZHANG Yong,ZHENG Qi-chang,LU Xin,QIN Tao.Department of General Surgery,Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Effect of Tumor Suppressor RECK Gene on Biological Behavior of Hepatocellular Carcinoma[J];Chinese Journal of Bases and Clinics in General Surgery;2006-02
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