A Clinical Study of Pemetrexed Combined with Cisplatin in the Treatment for Re-treated Advanced Breast Cancer
XU Zheng-yang,YANG Hui,YUAN Guang-bo,et al.(Yinzhou People's Hospital,Ningbo 315040,China)
[Purpose] To evaluate the efficacy and side effects of pemetrexed combined with cisplatin in the treatment for re-treated advanced breast cancer.[Methods] From Jan 2008 to Jan 2011,38 patients with re-treated advanced breast cancer pathologically proven who received combination of pemetrexed and cisplatin regimen.The efficacy and side effects were evaluated.[Results] All of 38 patients were evaluable for response.The response rate(RR) and disease control rate(DCR) were 39.5% and 73.7% respectively.The median time to progress(TTP) was 5 months and the median overall survival(OS) was 12 months.The main side effects were skin rash,mucositis,gastrointestinal toxicity and myelosuppression.[Conclusion] Pemetrexed combined with cisplatin in the treatment for re-treated advanced breast cancer is effective with mild toxicity.It deserves the clinical expansion and further exploration.
【CateGory Index】： R737.9