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《Journal of Chinese Oncology》 2012-02
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Hypermethylation of CpG Island in Promoter Region of hMSH2 in Esophageal Cancer

ZHOU Su-li1,2,MAO Wei-min1,LING Zhi-qiang1,et al.(1.Zhejiang Cancer Research Institute,Zhejiang Cancer Hospital,Hangzhou 310022,China;2.Taizhou Cancer Hospital,Taizhou 318000,China)  
[Purpose] To study the function of hMSH2 gene promoter region 5'-CpG island methylation in carcinogenesis of esophageal cancer.[Methods] The promoter region of hMSH2 5'-CpG island methylation was detected in 130 cases with esophageal cancer and adjacent normal tissues by real-time methylation-specific PCR(real-time MSP),and its relationship with clinicopathological parameters and prognosis was analyzed.[Results] In 130 cases with primary esophageal cancer,63(48.5%) cases occurred hMSH2 gene methylation in promoter region 5'-CpG island,cancer adjacent tissue methylation was found in 18(13.8%) cases,with statistically significant difference(P0.05).hMSH2 gene promoter 5'-CpG island hypermethylation related to patients'age,distant metastasis and prognosis(P0.05),but not to gender,lymph node metastasis and clinical stage(P0.05).[Conclusion] hMSH2 gene promoter region 5'-CpG island methylation is a frequent molecular event in esophageal cancer,and is one of the important reasons of causing defective mismatch repair.It may be play an important role in aging and carcinogenesis for esophageal cancer,and may be a potential prognostic factor.
【Fund】: 浙江省科技计划(2009C33143);; 浙江省自然科学基金资助项目(Y2080749、Y2091110);; 卫生部—浙江省重大科研基金项目(WKJ2010-2-004、WKJ2011-2-015);; 2011年度浙江省重大科技专项计划项目(2011C13039-1)
【CateGory Index】: R735.1
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