A Meta Analysis of Adjuvant Therapy for Esophageal Cancer Postoperation
MAO Wei-min,CHENG Lei(Zhejiang Cancer Hospital,Hangzhou 310022,China)
[Purpose] To investigate the value of adjuvant therapy for esophageal cancer postoperation.[Method] randomized control study articles about adjuvant treatment after esophagectomy from 1995 to 2011 were collected,and Stata12.0 software was used for Meta analysis.[Reasults] Compared with patients undergoing surgery alone,the 3-year progress free survival(PFS) in patients with adjuvant chemotherapy was significantly different,with RR 1.225(95%CI:1.012～1.482,P=0.037).But 3-,5-year overall survival rates(OS) with RR 0.899(95%CI:0.797～1.016,P=0.087) and 1.183(95%CI:0.97～1.442,P=0.098),respectively.3-year OS of adjuvant radiation patients was significantly different with that of the patients with surgery alone,RR0.935(95%CI:0.879～0.994,P=0.033).But 5-year OS with RR 0.988(95%CI:0.821～1.188,P=0.897).P values of Begg's and Egger test were greater than 0.05,indicating there was no publication bias in the study.[Conclusion] Postoperative adjuvant chemotherapy can improve the 3-year PFS in patients with esophageal cancer after surgery,while postoperative adjuvant radiation does not improve 3-year OS.
【CateGory Index】： R735.1