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《Journal of Chinese Oncology》 2012-02
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The Effect of Systemic Chemotherapy Combined with Local Hyperthermia in the Treatment for Patients with Advanced Gastric Cancer

LV Ya-lei,LIU Hui-zhi,ZHAI Bao-e,et al.(Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)  
[Purpose] To investigate the efficacy and side effects of systemic chemotherapy combined with local hyperthermia in patients with advanced gastric cancer.[Methods] One hundred and thirteen patients with advanced gastric cancer were divided into two groups:group HC received chemotherapy and regional hyperthermia;group C received chemotherapy alone.[Results] The overall response rates were 35.3% and 30.6% in group HC and group C respectively,with no significant difference(χ2=0.298,P=0.585).The clinical benefit response rate in group HC was significantly higher than that in group C(86.3% vs 43.5%,χ2=6.136,P=0.047).The quality of life improved and the pain relieved markedly in group HC.The main toxicities were gastrointestinal tract,liver toxicity,and myelosuppression.[Conclusion] Systemic chemotherapy combined with local hyperthermia might be an effective and safe treatment for patients with advanced gastric cancer.
【CateGory Index】: R735.2
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