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《Journal of Chinese Oncology》 2012-11
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Expression of Survivin,BRCA1 and class Ⅲ β-tubulin in Non-small Cell Lung Cancer and Its Relationship with Resistance to Paclitaxel

ZHOU Zheng-shi,LIAO Xiao-fang,ZHENG Qin-hong,et al.(Quzhou People's Hospital,Quzhou 324000,China)  
[Purpose] To investigate the relationship between the expression of Survivin,BRCA1 and class Ⅲ β-tubulin proteins and resistance to paclitaxel in patients with non-small cell lung cancer(NSCLC).[Methods] The expressions of Survivin,BRCA1 and class Ⅲ β-tubulin in 64 cases with NSCLC were detected by immunohistochemical method.Patients received paclitaxel-based chemotherapy.The relationship between the expression of 3 kinds of proteins and sensitivity of paclitaxel-chemothrapy was analyzed.[Results] The response rate(RR) of paclitaxel-based chemotherapy in patients with positive Survivin expression or positive class Ⅲ β-tubulin expression was lower than that in negative Survivin expression patients(27.8% vs 71.4%,P0.05) or negative class Ⅲ β-tubulin expression patients(23.5% vs 73.3%,P0.05).RR in positive BRCA1 expression patients was higher than that in negative BRCA1 expression patients(60.0% vs 31.0%,P0.05).Multivariate analysis showed that class Ⅲ β-tubulin was independent factor for progression-free survival(χ2=4.852,P=0.027) and stage was independent factor for overall survival(χ2=4.105,P=0.035).[Conclusion] Positive expressions of Survivin and class Ⅲ β-tubulin and negative BRCA1 expression in NSCLC patients might be associated with resistance to paclitaxel-based chemotherapy.
【CateGory Index】: R734.2
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