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《Journal of Chinese Oncology》 2012-11
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Clinical Study of Stereotactic Conformal Body γ-knife Combined with Adoptive Immunotherapy(Dendritic Cell and Cytokine-induced Killer Cell) in the Treatment for Advanced Non-small Cell Lung Cancer

ZHENG Fang-chao,ZHANG Xiao-yu,FENG Huai-zhi,et al.(452nd Hospital of People's Liberation Army,Chengdu 610021,China)  
[Purpose] To investigate the clinical effect of stereotactic conformal body gamma(γ)-knife combined with adoptive immunotherapy in the treatment for advanced non-small cell lung cancer(NSCLC).[Methods] Seventy-two patients with advanced NSCLC were divided into two groups randomly.Thirty-six patients of radiotherapy group were treated with stereotactic conformal body γ-knife alone and other 36 patients of joint group were treated with stereotactic conformal body γ-knife combined with adoptive immunotherapy(dendritic cell and cytokine induced killer cell,DC-CIK).The therapeutic effect was compared between two groups.[Results] Three months after treatment,immunological indicators including positive rate of CD3+CD56+,Th1/Th2 ratio and Ag-NOR ratio in patients of joint group were higher than those in patients of radiotherapy group(P0.05).Also,the PS score,ALT,CEA and CA125 were lower in patients of joint group than those in patients of radiotherapy group(P0.05).The median survival time of joint group was longer than that of radiotherapy group(P0.05).The incidence rates of leukocytopenia and acratia were lower in joint group than those in radiotherapy group(P0.05).[Conclusion] Stereotactic conformal body γ-knife combined with DC-CIK can improve immunity function and QOL in patients with advanced NSCLC,and reduce the incidence rate of side effects.
【CateGory Index】: R734.2
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