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《Journal of Chinese Oncology》 2012-11
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Clinical Study of Stereotactic Conformal Body γ-knife Combined with Adoptive Immunotherapy(Dendritic Cell and Cytokine-induced Killer Cell) in the Treatment for Advanced Non-small Cell Lung Cancer

ZHENG Fang-chao,ZHANG Xiao-yu,FENG Huai-zhi,et al.(452nd Hospital of People's Liberation Army,Chengdu 610021,China)  
[Purpose] To investigate the clinical effect of stereotactic conformal body gamma(γ)-knife combined with adoptive immunotherapy in the treatment for advanced non-small cell lung cancer(NSCLC).[Methods] Seventy-two patients with advanced NSCLC were divided into two groups randomly.Thirty-six patients of radiotherapy group were treated with stereotactic conformal body γ-knife alone and other 36 patients of joint group were treated with stereotactic conformal body γ-knife combined with adoptive immunotherapy(dendritic cell and cytokine induced killer cell,DC-CIK).The therapeutic effect was compared between two groups.[Results] Three months after treatment,immunological indicators including positive rate of CD3+CD56+,Th1/Th2 ratio and Ag-NOR ratio in patients of joint group were higher than those in patients of radiotherapy group(P0.05).Also,the PS score,ALT,CEA and CA125 were lower in patients of joint group than those in patients of radiotherapy group(P0.05).The median survival time of joint group was longer than that of radiotherapy group(P0.05).The incidence rates of leukocytopenia and acratia were lower in joint group than those in radiotherapy group(P0.05).[Conclusion] Stereotactic conformal body γ-knife combined with DC-CIK can improve immunity function and QOL in patients with advanced NSCLC,and reduce the incidence rate of side effects.
【CateGory Index】: R734.2
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Hu LUO,Xiangdong ZHOU Department of Respiratory Medicine,Southwest Hospital,the Third Military Medical School,Chongqing 400038,China;Researche Advances on CIK Cells and Their Clinical Use in Lung Cancer[J];Chinese Journal of Lung Cancer;2011-12
2 HUI Qing-shan,QIU Jian-wu(First Affiliated Hospital of Liaoning Medical College,Jinzhou121001,P.R.China);Influence of DC-exosomes vaccine combined with cisplatin on proliferation and apoptosis in human glioblastoma U251 cells[J];Shandong Medical Journal;2012-02
3 CAO Ya-juan1 YANG Jin-kun2,YANG Jin-zu2 1.Grade 2009 Postgraduate,Shanghai University of Traditional Chinese Medicine 2.Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Research advance in treatment of primary liver cancer with Cinobufacini injection[J];Shanghai Journal of Traditional Chinese Medicine;2012-04
4 CHEN Jian 1,ZHANG Xiaoyu 2,SUN Yi 1,GUI Yongzhong 1,LI Shuo 1,KUANG Hong 1,JING Xinrong 1,ZHONG Guocheng 1 1 Department of oncology,452nd Hosptal of People's Liberation Army(PLA);2 Department of Nuclear Medicine,452nd Hosptal of PLA,Sichuan Chengdu 610021,China.;Clinical effect of high intensity focused ultrasound combined with immunotherapy (dendritic cell and cytokine-induced killer cell) on advanced hepatocellular carcinoma( HCC)[J];Journal of Modern Oncology;2012-04
5 PAN Shi-yong.Department of Health Care,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,China;WANG Jun,PU Xiao-lin,LIU Fu-yin,FAN Wei-fei,YANG Min,MENG Li-juan.Department of Oncology,Jiangsu Provincial Geriatric Hospital,Nanjing 210024,China;Effect of dendritic cell derived tumor vaccine of elderly patients with non-small cell lung cancer on autologous tumor cells[J];Practical Geriatrics;2011-02
6 Zhang Xiaoyu1,Li Yingchun1,Ren Li2,Wang Zhuomin1,He Lanlan1,Chen Chenghong1,Zhong Guocheng3 1Department of Nuclear Medicine;2Department of Radiotherapy;3Department of Oncology,452nd Hospital of People's Liberation Army,Sichuan Chengdu 610021,China.;Clinical observation of deproteinised calf blood serum injection on radioactive adverse reaction in patients with nasopharyngeal carcinoma[J];Journal of Modern Oncology;2013-03
7 Zhao Zilin,Luo Min,Huang Liangyan,Wang Hongzhi,Liao Xiujie Interventional Treatment Center,303 Hospital of People's Liberation Army,Guangxi Nanning 530021,China.;Randomized comparative study between microwave ablation radioimmunotherapy and post-operative adjuvant chemoradiation for lung cancer[J];Journal of Modern Oncology;2013-08
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 JIANG Shu-lian,WEN Jian,DU Jian-xia(Nanjing No.2 Hospital,Nanjing 210003,China);Effect of Huachansu on cytokine-induced killer cells against hepatocellular carcinoma cells[J];Chinese Journal of Biochemical Pharmaceutics;2007-03
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