Research Progress of MicroRNA DNA Methylation in Gynecological Cancer
WU Jian-hong,DAI Yin-mei (Beijing Obstetrics and Gynecology Hospital of Capital Medical University,Beijing 100026,China)
MicroRNAs (miRNAs) are 22 nucleotides long non-coding RNA that regulate expression of protein-coding genes at the posttranscriptional level. These single-strand RNAs are considered to play crucial roles in many normal cellular processes,such as proliferation,differentiation, and apoptosis. Recent studies have shown that miRNA genes might be silenced in human tumors by aberrant hypermethylation or hypomethylation of miRNAs in gynecological cancer, which induce abnormality expression of downstream target gene and anticipate carcinogenisis of gynecological cancer.