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The Effect of S-1 Concomitant with Intensity Modulated Radiation Therapy in the Treatment for Elderly Advanced Esophageal Squamous Cell Carcinoma

SHI Peng-fei;ZHANG Xiao-ming;LIU Bao-gang;The First People's Hospital of Xianyang City;The Affiliated Hospital of Shaanxi Traditional Chinese Medicine University;  
[Purpose] To investigate the short-term response and safety of S-1 concomitant with intensity modulated radiation therapy(IMRT) in the treatment for elderly advanced esophageal squamous cell carcinoma(ESCC). [Methods] One hundred ESCC patients were divided into two groups,each group with 50 cases. All patients were applied with IMRT treatment,and the treatment group was applied with S-1 capsule in addition. After 3 cycles of chemotherapy,the shortterm response,1-year survival rate,local control rate,survival and toxicity were recorded. [Results] The short-term response rate of treatment group was 84.00%,which was significantly higher than that in the control group(62.00%,P 0.05). The 1-year survival rate,local control rate and survival of treatment group were much higher than those in the control group(P0.05). The rate of toxicity between two groups has no statistically difference(P0.05). [Conclusion] S-1 concomitant with IMRT has superior short-term response and less toxicity in the treatment for elderly advanced ESCC.
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