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Research Progress on Anaplastic Lymphoma Kinase-positive Diffuse Large B-cell Lymphoma

QIU Hui-fang;YANG Wen-jun;Affiliated Hospital of Hangzhou Normal University;  
Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma(ALK+DLBCL) is a rare subtype of DLBCL with characteristic morphologic,immunophenotypic and cytogenetic feature. Most cases follow an aggressive clinical course with a poor prognosis. Recognition is critical to the diagnosis of the disease. Selective ALK inhibitors might provide a potential therapeutic option for patients with this disease.
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