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Research Progress of Breast Cancer Stem Cell Related Signal Pathway and Its Inhibitor

ZANG Chuan-xin;LIU Rui-juan;ZHAO Wen-ge;SUN Yue;TANG Shi-feng;SUN Chang-gang;Rizhao Hospital of TCM;Weifang Traditional Chinese Medical Hospital;Weifang Medical University;  
Breast cancer stem cells are a few cells with self-renewal capacity and multi-directional differentiation in breast cancer tissue,which are closely related to the occurrence and development of breast cancer. At present,the clinical treatment of breast cancer is easy to metastasis and recurrence is related to the existence of breast cancer stem cells. Therefore,it is necessary to seek the treatment of breast cancer stem cells. And breast cancer stem cell signaling pathway plays a key role in the activation of breast cancer cell function,breast cancer cell differentiation and control of breast cancer cell division,breaking its balance status will lead to breast cancer cell growth and cancer. Therefore,targeted therapy for the corresponding pathway may become a new perspective of breast cancer treatment. This paper mainly expounds the research progress of hedgehog signaling pathway and its inhibitors,in order to provide reference for more effective clinical treatment for breast cancer patients.
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