Expressions of Plasma Calcium Ions,25-Hydroxyvitamin D,CaSR and E-Cadherin in Breast Cancer and Clinical Significance
HAN Xue;LIN Shan;ZHAO Zi-wei;Affiliated Zhongshan Hospital Dalian University;
[Objective] To investigate the expression of plasma calcium ions,25-hydroxyvitamin D[25(OH) D],calcium sensitive receptors(CaSR) and E-cadherin in breast cancer patients and their clinical significance. [Method] Three hundred and sixty patients with breast cancer receiving surgical resection in our hospital from February 2015 to February 2017(group A),100 patients with benign breast masses(group B) were enrolled in the study. Forty specimens of pericancerous tissue were collected from breast cancer patients were also collected(group C). The serum calcium ion levels were measured with by electrode method,25(OH)D levels were determined by enzymelinked immunosorbent assay(ELISA),the expression of E-cadherin and CaSR was detected by immunohistochemistry. [Results] The average plasma calcium ion and 25(OH)D levels in group A were lower than those in group B(P0.05). The positive rate of CaSR in group A was higher than that in group B and group C(P0.05). The positive rate of E-cadherin in group A was lower than that in group B and group C(P0.05). The expression of E-cadherin,CaSR,blood calcium and 25(OH)D was not correlated with TNM stage and pathological type(P0.05),but correlated with lymph node metastasis(P0.05). [Conclusion] Plasma calcium,25-hydroxyvitamin D,CaSR and E-cadherin are associated with breast cancer.