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《Journal of Xinjiang Medical University》 2018-09
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The value of PET/CT combined with CEA,CA125,CY21-1 and NSE in differential diagnosis of solitary pulmonary occupying lesions

YANG Min;WANG Jiao;XIONG Wei;ZHANG Xiongwen;Department of Emergency,The People′s Hospital of Leshan;Department of Nephrology,The People′s Hospital of Leshan;  
Objective To evaluate the value of positron computed tomography(PET/CT)combined with carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cytokeratin 19 fragment(CY21-1),neuron specific enolization.Methods A total of 243 patients with pulmonary space-occupying lesions admitted to our hospital from April 2015 to February 2018 were enrolled.All patients were examined PETCT and serum tumor markers,10 days before surgery.The diagnostic value of the histopathological,comparative analysis of simple tumor marker detection,PET-CT detection,combined detection of three ways was analyzed.Results(1)Among 243 patients,there were 195 lung cancer cases and 48 benign cases.The specificity,sensitivity and accuracy of tumor marker detection,PET-CT and combined detection were72.9%,62.1%,64.2%,47.9%,91.3%,82.7%,45.8%,97.4%,87.3%,respectively.The specificity of tumor markers detection method was the highest,but its accuracy was the lowest.The sensitivity of PETCT was the highest.The accuracy of combined detection was the highest,but its specificity was the lowest.(2)As the diameter of the tumor increases,the accuracy of the three detection methods gradually increases.For tumors with diameters less than or equal to 2 cm,3 cm,5 cm,and5 cm,the area under the ROC curve for tumor marker detection was the smallest.And the combined detection was the largest.(3)Smoking history,tumor maximum diameter,and lymph node metastasis were independent risk factors for PET-CT(SUVmax)(P 0.05).The effect on PET-CT SUVmaxwas as follows:tumor maximum diameterlymph node metastasissmoking history.(4)PET-CT SUVmaxand patient gender(r=-0.189,P=0.008),lung cancer maximum diameter(r=0.499,P =0.000),lung benign tumor maximum diameter(r=0.328,P =0.001),smoking History(r=0.208,P =0.002),anatomical position(r=-0.616,P =0.000),lymph node metastasis(r=0.210,P =0.003),pathological stage(r=0.333,P =0.000)were significant relevant relationship.Conclusion PET/CT combined with CEA,CA125,CY21-1,NSE can effectively improve the diagnostic efficacy of single lung cancer,and it has certain auxiliary diagnostic value for patients who cannot obtain pathological diagnosis by traumatic examination.
【Fund】: 四川省卫生和计划生育委员会科研课题(17PJ046)
【CateGory Index】: R734.2
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