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《Advances in Psychological Science》 2017-12
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Endoplasmic reticulum stress and posttraumatic stress disorder

HAN Fang;LIU Hong;XIAO Bing;LIU Dongjuan;WEN Lili;ZHAO Wei;KONG Fanzhen;ZHAO Dongmei;LI Xiaoyan;SHI Yuxiu;Department of Histology and Embryology, Lab of PTSD, Basic Medical College,China Medical University;  
Endoplasmic reticulum stress(ERS) induce the protein folding reaction, and then make endoplasmic reticulum three pathway PERK, IRE1 and ATF6 separate from the endoplasmic reticulum chaperone, activate of three pathways and start the apoptosis pathway. We used the animal model of posttraumatic stress disorder: single prolonged stress(SPS) to find endoplasmic reticulum stress cause the endoplasmic reticulum chaperone and protect neurons at the early stage of SPS, but in the later period of SPS, when the ability decreased that endoplasmic reticulum chaperone correct for the folding protein, ERS could accelerate the activation of three path and induce the cell apoptosis.
【Fund】: 国家自然科学基金项目(81571324)
【CateGory Index】: R749.5
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