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《Advances in Psychological Science》 2017-12
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Imbalance of central immunity and cognitive dysfunction: The role of TNFα

ZHANG Yu;LIN Wenjuan;WANG Weiwen;CAS Key Laboratory of Mental Health, Institute of Psychology;University of Chinese Academy of Sciences;School of Nursing, Binzhou Medical University;  
Central immune activities exert important roles in maintaining homeostatic process of central nervous system. It has shown that the dynamically balance of brain TNFα participates in the regulation of neurodevelopment, synaptic plasticity and cognitive function by its receptor signaling, while imbalance of TNFα signaling, no matter excessive or insufficient, can result in adverse effects on brain function and behavior. Stress, especially early stress, may disturb the dynamic development process of TNFα signaling and thus cause lasting alterations of its expression and receptor function, which strongly linked to the increasing incidences of immune-related psychopathological disorders in late life. Future studies are needed to deepen the understanding of causal relationships between central immunity and cognitive dysfunction, and establish new strategies for disease prevention and treatment based on immunoregulation.
【Fund】: 国家自然科学基金(No.81471122 and No.31470988);; 中国科学院(KJZD-EW-L04);中国科学院心理健康重点实验室(中国科学院心理研究所)资助
【CateGory Index】: B845.1
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