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《Advances in Psychological Science》 2017-12
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The role and mechanisms of DNA epigenetic modification in drug related memory

ZHANG Jian-Jun;JIANG Feng-Ze;SUI Nan;CAS Key Laboratory of Mental Health, Institute of Psychology;Department of Psychology, University of Chinese Academy of Sciences;  
DNA epigenetic modification includes DNA methylation, which was catalyzed by the DNA methyltransferase, and DNA demethylation, which was mediated by the Ten-eleven translocation enzymes. Both of them induce the changes of neural activity and behavior through responding environmental stimulus and regulating gene expression. Massive studies suggested that DNA methylation is one of the most important mechanisms in the drug related memory. In recent years, it was found that DNA demethylation involved in controlling fear memory and addiction behavior. As a result, the effects of DNA epigenetic modification on drug related memory should be reassessed. This review focuses on the co-regulation of DNA methylation and demethylation in drug related memory, then we discuss the probable regulatory mechanisms and try to put forward the vista of further study.
【Fund】: 国家重点基础研究发展计划(2015CB553501);; 国家自然科学基金(91332115、31400880)资助
【CateGory Index】: B845.4
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