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《Advances in Psychological Science》 2017-12
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Maternal peripartum depression induced transgenerational depressive disorder and mechanisms

WU Ruyan;XIA Baomei;WANG Wei;XU Guihua;CHEN Gang;Department of Medical Psychology, Medical School, Yangzhou University Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases;Nanjing Normal University of Special Education, Faculty of Rehabilitation Science, Department of Rehabilitation;School of Psychology, Nanjing University of Chinese Medicine;Nanjing University of Chinese Medicine, Center for Translational Systems Biology and Neuroscience Key laboratory of TCM Brain Research;School of Nursying, Nanjing University of Chinese Medicine;  
Peripartum depression(PPD) has adverse effects on both mothers and offpring, particularly by increasing the risk of emotional disorders in offspring significantly in a transgenerational manner. The pathogenesis of transgenerational depressive disorders from PPD is complex, and the current pharmacotherapeutic efficacy was limited. Therefore, it is of great importance to study the mechanisms underlying this disorder. We discuss the role of the hypothalamic-pituitary-adrenal axis(HPA), oxytocin(OT), synaptic plasticity and epigenetic mechanisms underlying transgenerational depressive disorders, to give insight for further in-depth research.
【Fund】: 国家自然科学基金(81 67 36 25);; 江苏自然科学基金(BK20151568);江苏省自然科学基金(BK20170517);江苏省自然科学基金(BK20170769);; 江苏省双创项目(2013455);; 江苏六大人才高峰项目(2013-YY-11);; 江苏省优势学科;; 国家自然青年基金(81701340)
【CateGory Index】: R749.4
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