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《Chinese Journal of Animal and Veterinary Sciences》 1956-02
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THE TREATMENT OF GLANDERS BY THE SULPHAMEZATHINE-MALLEIN METHOD

T. P. HU, M.R.C.V.S. T.K. CHU, S. W. CHOU, et al  
In experiments of testing the effectiveness of the Sulphamezathine-Mallein method in the treatment of various forms of glanders in horses and asses, we found that its therapeutic action varied according to the forms of the disease. (1) The Sulphamezathine-Mallein (SMT-M) therapy has definite curative action on artificially infected horses and asses, and on naturally infected cases of glanders in their initial stages of infection. In 23 cases of artificially infected asses, SMT-M produced 73.9% cure; but when Sulphathiazole was substituted for SMT, the rate of cure was only 33.3% in 9 cases under treatment. 10 control animals (i. e. those infected but received no treatment) all died of acute glanders. In 48 horses inoculated with virulent cultures of glanders bacilli, the rate of cure was 85% after the SMT-M treatment. The criteria of cure in such cases were the disappearance of both allergic and serological reactions and the negative findings in pathological and bacteriological examinations. On the other hand, 15 out of 17 control animals presented more or less fresh glanderous lesions in their organs upon post-mortem examination, and the 2 remaining cases continued to react positively to the ophthalmic mallein test, while those animals proclaimed to be cured had long since ceased to do so. In 15 out of 20 recently infected horses the reaction to mallein and complement-fixation tests disappeared in 3-6 months after treatment, and when 11 of them were post-mortemed, no lesions could be found. The rate of cure was estimated to be 75%. The other 5 cases retained their reactions and, upon post-mortem, 4 of them presented no sign of being cured and one case was totally devoid of lesions. (2) SMT-M has little if any effect at all on the chronic forms of glanders in horses, including those giving only positive reactions to the mallein test. 116 cases were treated, but the result was disappointing. It appears to us that the SMT-M method. could be recommended for practical application on the early stages of acute form of glanders, but it would be almost useless when applied to the chronic form of the disease. The effect obtained by us was much lower than that reported by the Army Veterinary Authorities in Iran. The discrepancy was explained by the possible differences in the breeds of horses in the two countries and in the forms of the disease selected for treatment
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