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IMMUNOHISTOCHEMICAL DYNAMIC STUDIES ON INCLUSION BODY HEPATITIS IN CHICKENS

Liu Jianmin 1,Hu Weihua 2 ,Xu Funan 1,Liu Juxiang 2 ,Wu Xianjun 2 (1 Veterinary College of Nanjing Agricultural University,210095; 2 College of Animal Science,Hebei Agricultural University,071001)  
Immunohistochemical dynamic changes of inclusion body hepatitis (IBH) were studied following the oral administration of a serotype 8 strain of avian adenovirus into 3 day old chickens.The results showed that the adenovirus had an affinity to the epithelia,lymphocytes,the blood vessel and sinus endothelium and erythrocytes in the livers,thymuses,bursas,spleens,intestines,kidneys and pancreases.In addition,during 12 h 2days,9 days 11 days post inoculation(pi),the nuclei of most organs were positive twice.The positive particles in the nuclei have two kinds of appearances:large and fine particular.
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