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《Chinese Journal of Animal and Veterinary Sciences》 2004-01
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Neuroprotective Effect of Metallothionein in Cerebral Ischemia-reperfusion Injury of Rats

LIU Xue-zhong~1,CUI Xu~2,WANG Han-dong~1,WANG Zong-yuan~1(1.Department of Veterinary Medicine,Animal Science and Veterinary Medicine College,YangzhouUniverstiy,Yangzhou 225009,China;2.Institue of Gerontology and Geriatrics,Departments of Neurobiology and Neurology,PLA General Hospital,Beijing 100853,China)  
In order to study neuroprotective effect of metallothionein-1(MT-1) in cerebral ischemia-reperfusion(IR) injury,we used bilateral carotid arteries occlusion model of rats and analysised the changes of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and malondialdehyde(MDA) in the brain tissue at 6 h?1 d?3 d and 5 d after reperfusion following 10min forebrain ischemia.The results showed in predeterminate time,the activity of SOD and GSH-Px in rat brain tissues in old group was significantly lower than that in young group (P0.05).The content of MDA was significantly higher than that in young group (P0.05),and MT-1 could increase the activity of SOD and GSH-Px,halt lipid peroxidative reactions in brain (P0.01).It has been tested that MT-1 can protect brain tissue from IR injury.
【Fund】: 国家重点基础研究发展规划项目(G2000057000);; 扬州大学科研基金项目(3550)资助。
【CateGory Index】: S852.2
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