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《Chinese Journal of Animal and Veterinary Sciences》 2004-01
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Safety and Efficacy of PrV Ea TK~-/gE~-/gI~- Gene-deleted Vaccine

LIU Zheng-fei,CHENG Huan-chun,WU Bin,JIN Mei-ling,HE Qi-gai(College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 4370070,China)  
In this article,the safety and efficacy of PrV Ea TK~-/gE~-/gI~- gene deleted vaccine was studied systemically.The vaccine is safe when it was inoculated to pregnant sows,newborn piglets and finishing pigs with 10~(5.0)TCID_(50) and 10~(6.0)TCID_(50) vaccine dose and can protected sows after challenged with 10~(6.0)TCID_(50) PrV Ea field strain.GE antibody can not be produced in the serum of piglets a month later.The neutralization antibody increase greatly after second inoculation with the vaccine.Moreover PrV Ea TK~-/gE~-/gI~- vaccine strain is biologically very safe to rabbits,cat and milk goats.
【Fund】: 国家863计划项目(2002AA241341);; 国家自然科学基金资助项目(30170701)。
【CateGory Index】: S852.4
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