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《Chinese Journal of Animal and Veterinary Sciences》 2004-01
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Study on the Pathological Changes and Mechanism of Apoptosis in Chickens Artificially Infected with Marek's Disease Virus

QI Bao-min~1,YAO Jin-shui~1,CHEN Wen-lie~2,LU Hui-ming~1(1.College of Animal Sciences,Fujian Agricalture and Forestry University,Fuzhou,350002;2.Laboratory of Eelctron Microscopy,Fujian Medical University,Fuzhou,350000)  
The apoptosis and its mechanism of parenchymal cells of chickens artificially infected with Marek's disease virus (MDV) was studied by the methods of histopathology,ultrastructural pathology and immunohistochemistry.The results showed that the parenchymal cells of liver,hert,spleen,glandular stomach,ovary and feather pulp exhibited obvious apoptosis.Histopathologically,the nucleus of hepatocyes,renal tabular epithelial cells,glandular epithelial cells of glandular stomach,myocardial myocytes,lymphocytes of spleen,cells of granulosa in ovary and cells of feather pulp were fragmented into several condensed and round pieces.Utrastructurally,apoptosis underwent several phases,included chromatin condensed,marginated and fragmented,at last,formed apoptotic bodies.The immunohistochemical results indicated that all cells above-mentioned expressed FasL(Fas ligand) obviously.The expession of FasL indicated enhancement of apoptotic signals and accurrence of apoptosis.
【Fund】: 福建省自然科学基金资助项目(C9810024)
【CateGory Index】: S852.65
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