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《Chinese Journal of Animal and Veterinary Sciences》 2004-01
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Experimental Studies on Endotoxin-induced Acute Renal Failure

ZHOU Jian-guo,WU Li-fu(Department of Veterinary Medicine,Guizhou University,Guiyang 550025,China)  
The model group rabbits were given two intravenous injections of E.coli O_(111)B_4 endotoxin with an interval of 24 hours(15 μg·kg~(-1) and 35 μg·kg~(-1) respectively).From the second hour after the 2nd injection,serial urine samples were collected by a bladder fistula at 1 h intervals for six hours.After the collection of the urine samples bleeding was immediately made from heart.Urinary output,plasma and urine level of creatinine and urea nitrogen,serum and urine level of sodium and the osmotic pressure of serum and urine were measured.The excretion of creatinine and urea nitrogen,endogenic creatinine clearance(a reflection of glomerular filtration rate),urinary sodium excretion,renal failure index and fractional excretion of sodium,the ratio of urinary osmotic pressure to serum osmotic pressure,osmotic clearance and free water clearance were calculated on the basis of the above determination.The results showed that urinary output and the excretion of creatinine and urea nitrogen were significantly decreased(P0.05,P0.01,P0.001),urinary sodium,renal failure index and the fractional excretion of sodium were markedly increased(P0.05,P0.01),glomerular filtration rate,urinary osmotic pressure,the ratio of urinary osmotic pressure to serum osmotic pressure and osmotic clearance was significantly declined(P0.05,P0.01,P0.001) as compared with the saline-injected control rabbits,and the free water clearance tended to zero.
【Fund】: 贵州省自然科学基金资助项目[黔基合计字(2001)3035号]
【CateGory Index】: S852.3
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【References】
Chinese Journal Full-text Database 2 Hits
1 Wang Hua;Zhou Xiaoqiong;Li Yan;Chen Xiaohong;College of Life Sciences, Longyan University;;Comparative on Effects of three Traditional Chinese Medicine Preparations on Acute Renal Failure[J];中国农学通报;2013-32
2 WU Li-fu~1, ZHOU Jian-guo~(1,2) (1.Department of Veterinary Medicine, Guizhou University, Guiyang 550025,China; 2.Yunnan Veterinary Service Centre, Kunming 650051, China);Experimental Studies on Pathogenesis of Endotoxin-induced Acute Renal Failure[J];畜牧兽医学报;2005-03
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 HAN Cui-cui1,LIANG Xue1,DUAN Feng-li2(1.Heilongjiang University of Chinese Medicine,Harbin 150040,China; 2.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China);The Effect of Yishen Jiangzhuo Decoction on Renal Function of Mice with Chronic Renal Failure[J];中医药信息;2012-01
2 Cao Yixin1 Zhang Xu2 Zhang Cuiwei2 He Ying3 Ma Yuerong2 1(Department of Histology and Embryology,Luzhou Medical College,Luzhou 646000,China)2(Department of Pathology,Luzhou Medical College,Luzhou 646000,China)3(Traditional Chinese Medicine Laboratory of Pharmacy School,Luzhou Medical College,Luzhou 646000,China);Protective Effect of Tanshinone ⅡA on Kidney in Acute Renal Failure Rats[J];四川解剖学杂志;2011-02
3 ZHANG Cui ( Guangdong College of Pharmacy,Guangzhou 510006,China);Screening of eight Chinese herbal medicines activating blood circulation and dissipating blood stasis against endotoxin[J];山西医科大学学报;2010-07
4 Zhou Jinxing,Ning Kangjian,Wang Jue,Li Shenghe,Yin Dingzhong,Feng Baoming (College of Animal Science,AnHui Science and Technology University,Fengyang AnHui 233100);The Prevention and Cure Effect of Two Different Chinese Traditional Medicine Injection on the Endotoxin Renal Failure[J];中国农学通报;2010-03
5 ZHOU Da-yong,ZHANG Zong-ming,HAN Ning-lin,et al.The first Affiliated Hospital of Anhui College of TCM,Hefei 230031,China;Effects of reduqing (RDQ) on plasma nitric oxide levels in rabbits with endotoxic induced fever[J];中国实用医药;2007-22
6 GAO Yong-lin ,WU Li-fu (Department of Veterinary Medicine, Guizhou University, Guiyang 550025,China);Preventive Effect of Injectio Reduqing on Endotoxin-induced Acute Renal Failure[J];畜牧兽医学报;2004-03
7 ZHOU Jian-guo,WU Li-fu(Department of Veterinary Medicine,Guizhou University,Guiyang 550025,China);Experimental Studies on Endotoxin-induced Acute Renal Failure[J];畜牧兽医学报;2004-01
8 Guo Deyu; Qiao Yiran; Cheng Yishen(Dept of Pathol, Third Military Medical College, Chongqing 630038);An experimental study on lipopolysaccharide-induced renal pathological changes and their mechanisms in rats[J];临床与实验病理学杂志;1995-03
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 ZHOU Jin-xing,LI Sheng-he,FENG Bao-ming(College of Animal Science,Anhui Science and Technology University,Fengyang 233100,China);Effect of Compound Honeysuckle and Herba Artemisiae Scoparia Injection on Tissue Structure of Endotoxin-Induced Acute Renal Failure in Rabbits[J];安徽科技学院学报;2012-02
2 TIAN Ye1,PANG Hong-yu2,SUN Guo-liang2,LI Xiao-yun2,WEI Jing2,HEI Zi-qing2(1Department of Anesthesiology,People's Hospital of Zhongshan City,Zhongshan 528403,China;2Department of Anesthesiology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China.);Function of gap junction in NRK52E cells exposed to bilirubin combined with lipopolysaccharide[J];中国病理生理杂志;2011-08
3 Zhou Jinxing,Ning Kangjian,Wang Jue,Li Shenghe,Yin Dingzhong,Feng Baoming (College of Animal Science,AnHui Science and Technology University,Fengyang AnHui 233100);The Prevention and Cure Effect of Two Different Chinese Traditional Medicine Injection on the Endotoxin Renal Failure[J];中国农学通报;2010-03
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