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《Chinese Journal of Animal and Veterinary Sciences》 2004-01
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Experimental Studies on Endotoxin-induced Acute Renal Failure

ZHOU Jian-guo,WU Li-fu(Department of Veterinary Medicine,Guizhou University,Guiyang 550025,China)  
The model group rabbits were given two intravenous injections of E.coli O_(111)B_4 endotoxin with an interval of 24 hours(15 μg·kg~(-1) and 35 μg·kg~(-1) respectively).From the second hour after the 2nd injection,serial urine samples were collected by a bladder fistula at 1 h intervals for six hours.After the collection of the urine samples bleeding was immediately made from heart.Urinary output,plasma and urine level of creatinine and urea nitrogen,serum and urine level of sodium and the osmotic pressure of serum and urine were measured.The excretion of creatinine and urea nitrogen,endogenic creatinine clearance(a reflection of glomerular filtration rate),urinary sodium excretion,renal failure index and fractional excretion of sodium,the ratio of urinary osmotic pressure to serum osmotic pressure,osmotic clearance and free water clearance were calculated on the basis of the above determination.The results showed that urinary output and the excretion of creatinine and urea nitrogen were significantly decreased(P0.05,P0.01,P0.001),urinary sodium,renal failure index and the fractional excretion of sodium were markedly increased(P0.05,P0.01),glomerular filtration rate,urinary osmotic pressure,the ratio of urinary osmotic pressure to serum osmotic pressure and osmotic clearance was significantly declined(P0.05,P0.01,P0.001) as compared with the saline-injected control rabbits,and the free water clearance tended to zero.
【Fund】: 贵州省自然科学基金资助项目[黔基合计字(2001)3035号]
【CateGory Index】: S852.3
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1 WU Li-fu~1, ZHOU Jian-guo~(1,2) (1.Department of Veterinary Medicine, Guizhou University, Guiyang 550025,China; 2.Yunnan Veterinary Service Centre, Kunming 650051, China);Experimental Studies on Pathogenesis of Endotoxin-induced Acute Renal Failure[J];Chinese Journal of Animal and Veterinary Sciences;2005-03
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【Secondary References】
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1 HUANG Wei-xin LIU Jun-fu LIU Jian-chi XIE Ming-xin DAI He LIANG Teng-bing LIANG Chao-yue CHEN Hui (Grade 2004,Department of Clinicl Medicine Sciences,Guangxi Medical University,Nanning,Guangxi 530021,China);Complete bilateral ureteral obstruction impacts on the renal function of rabbits[J];Journal of Youjiang Medical College for Nationalities;2008-01
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