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Effect of Dietary High Copper on Tissue Structure and Biochemical Parameters of Kidney in Chickens

CUI Wei,LI Min,PENG Xi,DENG Jun-liang,CUI Heng-min(Key Laboratory of Animal Diseases and Environmental Hazards in Sichuan Universities /College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China)  
The experiment was conducted with the objective of examining the effect of dietary high copper on the renal tissue structure and biochemical parameters in chickens.360 one-day-old Avian chickens were randomly divided into six groups and feed on diets as follows: Controls(Cu 10.89 mg·kg-1) and high copper groups(Cu 100 mg·kg-1,high copper groupⅠ;Cu 200 mg·kg-1,high copper groupⅡ;Cu 400 mg·kg-1,high copper group Ⅲ;Cu 600 mg·kg-1,high copper group Ⅳ;Cu 800 mg·kg-1,high copper groupⅤ) for six weeks.Injuries were appeared in high copper groups Ⅲ,Ⅳ and Ⅴwhen compared with the control group,there were granular degeneration and vacuolar degeneration in the renal tubule epithelial cells.And,the renal copper contents and serum copper contents were much higher in high copper groups Ⅲ,Ⅳ and Ⅴ than that in control group(P0.01).Also,in high copper groups Ⅲ,Ⅳ and Ⅴ,the renal malondialdehyde and hydroxy radical contents were increased(P0.01),and the renal cuprozinc-superoxide dismutase(CuZn-SOD) activities were decreased(P0.01) compared with those of control group.The result showed that dietary copper exceed 400 mg·kg-1 caused pathological injures and the impaired antioxydant function in kidney,and finally impaired renal function.
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