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《Chinese Journal of Animal and Veterinary Sciences》 2019-01
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N~6-methyladenosine Modification in mRNA and Its Research Advance in Animals

LU Zengkui;ZHANG Liping;LI Qing;LIU Enmin;DU Lixin;CHU Mingxing;WEI Caihong;Institute of Animal Science,Chinese Academy of Agricultural Sciences;College of Animal Science and Technology,Gansu Agricultural University;  
The N~6-methyladenosine(m~6 A)modification is the most abundant RNA modification in animals,and is dynamically regulated by methyltransferase,demethylase and m~6 A binding protein.In mRNA,m~6 A modification can regulate most RNA metabolism processes and play an important physiological role in animals.In this review,the research progress of distribution and expression,detection methods,enzymes related to methylation metabolism and their physiological functions of m~6 A modification in animals are well introduced.Besides,the existing problems or challenges in the current m~6 A modification research are prospected in the present study,which will provide reference for further study on m~6 A modification.
【Fund】: 国家肉羊产业技术体系项目(CARS-38);; 国家自然科学基金(31672380)
【CateGory Index】: S813.1
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