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《Chinese Journal of Animal and Veterinary Sciences》 2019-01
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The Interaction between Farnesol (Quorum Sensing Molecule) and Candida albicans

YANG Aining;MA Xiaoping;GU Yu;YU Yan;HU Jing;JIANG Yaozhang;PENG Guangneng;ZHONG Zhijun;ZUO Zhicai;Key Laboratory of Animal Disease and Human Health,Sichuan Province,College of Veterinary Medicine,Sichuan Agricultural University;College of Life Science,Sichuan Agricultural University;  
Quorum sensing (QS) was first discovered in bacteria.It has also been found in fungi in recent years.The key signal molecule of QS are called Quorum sensing molecules (QSM),which excreting,sensing,responsing and acting on itself,and having no toxic action on itself when at the concentration that just cause the reaction.Farnesol is the QSM of Candida albicans,which influence multitudes factors of C.albicansincluding drug resistance,hypha formation,adhesive power and apoptosis;and influence the C.albicans host's immunity and host cell apoptosis.Furthermore,C.albicans has higher tolerance to farnesol than other fungi,but the mechanism is unclear.At present,because of the little understanding on the mechanism of the QSM farnesol,the interaction between the QSM farnesol and C.albicans is reviewed in this paper.
【Fund】: 四川省科技厅基础研究计划项目(2018JY0183);; 国家现代农业产业技术体系四川肉牛创新团队项目(035Z2388);; 大熊猫国际资金项目(AD1415);; 四川省科技计划项目(2018NZ002);; 国家重点研发计划项目(2018YFD0501800)
【CateGory Index】: S852.66
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