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《Animal Husbandry & Veterinary Medicine》 2019-01
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Effects of Aspergillus fumigatus infection in broilers on some immune indexes

ZHANG Guizhi;JIN Shuangxing;LI Xinzheng;HAN Zhanbing;Henan University of Animal Husbandry and Economy;  
This study was to investigate the effects of Aspergillus fumigatus infection on serum immunoglobulin,IFN-γ concentration and IBD antibody titer in broilers. 96 15-day-old Rose 308 broilers were selected and randomly divided into experimental and control groups,with 4 replicates in each group and 12 chickens per replicate. The experimental group was inoculated with mold spores for 5 days,and the control group was inoculated with normal saline. On 3 d,4 d and 5 d,two chickens were randomly selected from each replicate for the diagnostic tests. On 7d,the contents of Ig A,Ig G,Ig M,IFN-γn and IBD antibody in the serum were tested. The results showed that Aspergillus fumigatus was isolated from the blood of the 3d to 5d tested chickens. The concentrations of Ig A,Ig G and Ig M in the tested group were significantly lower than those in the control group (P0. 01),the serum IFN-γ concentration was significantly higher (P0. 01) and the titer of the IBD antibody was significantly lower (P0. 01). It could be concluded that Aspergillus fumigatus infection in chickens significantly reduced their immune function.
【Fund】: 河南省重大科技专项计划项目(161100510200);; 校科技创新团队项目(HUAHE2015003)
【CateGory Index】: S858.31
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【Citations】
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1 LUO Jing;CHEN Yi-qiang;KONG Jin-liang;HUANG Hong;WANG Ke;LI Bing;Institute of Respiratory Disease,First Affiliated Hospital of Guangxi Medical University;;In vitro antifungal activity of citral in combination with amphotericin B against amphotericin B-resistant Aspergillus fumigatus[J];实用医学杂志;2015-04
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