The mechanisms of the changes in endocrine function of pancreatic islet B-cells after pancreatic duct obstruction
Li Zhan-jing, et al. General Hospital of Chengdu Command Unit, PLA
Pancre atic duct obstruction (PDO) was performed with an a-cyanoacrylate glue in 8 healthy beagles. Pancreatic biopsies were taken in 5 of the animals. Biop sies were studied on histology and ultrastructure in order to reveal the mechanisms in the decrement of the endocrine function of pancreatic islet B-cells. The exocriae tissue was almost replaced by fibrodid with scattered inflammatory cells. Pancreatic islets were edematous and fibrosis. B-cells were damaged in different degrees. Our results show that the hypoinsulinisms are mainly due to the decrease of the number of the B-cells, the structural damages and metabolic disturbance of the residual B-cells, as well as the microenvironmen tdisorder in the pacreas islets.