Clinical study of plasma angiotensin Ⅱ(AII),atrial natriuretic peptide(ANP) and AII/ANP ratio in postburn multiple organ failure (MOF)
Liu Degui 1, Yang Zongcheng 2, Yang Yong 1, Cheng Chongdian 1, Li Jin, Wang Hongmei 1 1.Department of Burn and Plastic Reconstruction Surgery, General Hospital of Chengdu Military Command, Chengdu, 610083. 2.Instiute of burn injury, Southwest Hospital if Third Military Medical university, Chongqing, 400038.
Plasma angiotensin Ⅱ(AII), atrial natriuretic peptide(ANP), and AII/ANP ratio and N-acetyl-β-D-glocosaminidase (NAG) in blood samples from burn patients were determined. The results demonstrated that AII, ANP, AII/ANP, NAG of these patients increased significantly. The increased level of AII/ANP correlated positively with the extent of burn injury, as well as the severity of post-burn multiple organs failure(MOF). Therefore it was suggested that the imbalance of AⅡ/ANP played an important role in the pathogenesis of post-burn MOF, and AII/ANP and NAG could be used to determine the severity of post-burn MOF and prognosis of severe burn patients.
【CateGory Index】： R644