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《Medical Journal of National Defending Forces in Southwest China》 2014-01
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Value of vascular endothelial growth factor in the diagnosis and prognosis of Ewing's sarcoma

Zhao Zhengju;Cheng Hao;Xiang Yiming;Wu Jian;Luo Juying;Department of Surgery,Clinical College,Hubei University of Science and Technology;Department of Vertebral Column Joint,Central Hospital of Xianning City;School of Nursing,Hubei University of Science and Technology;  
Objective To study the expression of vascular endothelial growth factor( VEGF) in Ewing's sarcoma,and to provide reference for its diagnosis and prognosis. Methods Eighteen patients,who were histopathologically diagnosed as Ewing's sarcoma and had not received chemotherapy or radiotherapy yet between January 2009 and November 2012,were selected as the case group. The blood samples of all the patients before and after the chemotherapy were collected,and the level of VEGF in their sera was detected.Furthermore,20 healthy people who received the health examination in the hospital were selected as control group. And the VEGF level in their sera was also detected. Results The average level of serum VEGF of 18 cases of Ewing's sarcoma was 4547. 78 pg / ml,and that of the control group was 175. 8 pg / ml. Compared with the latter one,the former significantly increased( P 0. 01). Among the patients receiving the neoadjuvant chemotherapy,their levels of serum VEGF significantly decreased after the chemotherapy( P 0. 01).Conclusion The serum VEGF level of the patients with Ewing's sarcoma significantly increases. The comparison between the VEGF level before and after the chemotherapy may be used as a marker for the prognosis of those patients.
【Fund】: 湖北科技学院校级科研基金资助项目(KY09082)
【CateGory Index】: R738.1
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 GAO Hong,ZHANG Zhi-bo,ZHANG Ke-ren. Major Laboratory of Health Ministry for Congenital Malformations,Department of Pediatric Surgery,Shengjing Hospital (2nd Affiliated Hospital) of China Medical University,Shenyang 110004,China;VEGF and its receptor KDR,EG-VEGF in hepatoblastomas[J];中华小儿外科杂志;2004-03
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Zhao Zhengju;Cheng Hao;Xiang Yiming;Wu Jian;Luo Juying;Department of Surgery,Clinical College,Hubei University of Science and Technology;Department of Vertebral Column Joint,Central Hospital of Xianning City;School of Nursing,Hubei University of Science and Technology;;Value of vascular endothelial growth factor in the diagnosis and prognosis of Ewing's sarcoma[J];西南国防医药;2014-01
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