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《Medical Journal of National Defending Forces in Southwest China》 2014-01
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Research on suppression of colony-forming unit-erythroid by EPO monoclonal antibody

Huang Xuewen;Li Suzhi;Huang Yue;Xie Xiaoe;Liu Houdong;Yan Chuncheng;Shi Quangui;Ding Haoping;He Feng;Chen You;Department of Mountain Sickness,General Hospital of Tibet Military Command;  
Objective To study whether EPO monoclonal antibody can inhibit the formation of colony-forming unit-erythroid( CFU-E). Methods Marrow samples collected from rats received oriented culture for CFU-E. According to the different culture conditions,the samples were divided into blank control group( without EPO),conventional group( with EPO,but without EPO monoclonal antibody),and intervention group with EPO monoclonal antibody( EPO + EPO monoclonal antibody). After the culturing for 168 hours,the levels of CFU-E in each group were observed. Results The average colony counts of CFU-E in the blank control group, conventional group,and EPO monoclonal antibody intervention group were 0. 0 ± 0. 0,151. 8 ± 23. 3,and 10. 7 ± 3. 9,respectively. There were significant differences in the colony counts of C-FUE among the three groups( P 0. 01). Conclusion EPO monoclonal antibody can significantly inhibit the formation of CFU-E and the erythron proliferation. It is a possible medicine for the treatment of high altitude polycythemia.
【Fund】: 拉萨市科技局资助合作项目(2004078)
【CateGory Index】: R392
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Suzhi,Huang Xuewen,Huang Yue,Liu Houdong,Sun Zeping,Yan Chuncheng,Shi Quangui,He Feng,He Guiqiang,Chen You,Wang Yuliang,Pan Li,Yang Dingzhou,Long Renling,Zhao Haichao The General Hospital of Tibet Military Command,Lhasa (850000);EPO Monoclonal Antibody Preparation[J];高原医学杂志;2010-01
2 HUANG Xue-wen~1,LI Su-zhi~2,GAO Yu-qi~1,MU Xin-bin~2,SHI Quan-gui~2,HE Gui-qiang~2,SUN Ze-ping~2,HONG Yong~2,LI Xuan~2,ZHENG Jian-bao~2,WANG Hong-bin~2,HUANG Wen-chao~2,SAN Wei~2 1.Department of High Altitude Military Medicines,Third Military Medical University,Chongqing,400038;2.General Hospital of Tibet Military Command,Lhasa,850003;;Effects of polyclonal antierythropoietin antibody on stimulating colony-forming unit-erythropoiesis[J];西南国防医药;2006-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Huang Xuewen;Li Suzhi;Huang Yue;Xie Xiaoe;Liu Houdong;Yan Chuncheng;Shi Quangui;Ding Haoping;He Feng;Chen You;Department of Mountain Sickness,General Hospital of Tibet Military Command;;Research on suppression of colony-forming unit-erythroid by EPO monoclonal antibody[J];西南国防医药;2014-01
2 Li Suzhi,Huang Xuewen,Huang Yue,Liu Houdong,Sun Zeping,Yan Chuncheng,Shi Quangui,He Feng,He Guiqiang,Chen You,Wang Yuliang,Pan Li,Yang Dingzhou,Long Renling,Zhao Haichao The General Hospital of Tibet Military Command,Lhasa (850000);EPO Monoclonal Antibody Preparation[J];高原医学杂志;2010-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 HUANG Xue-wen~1,LI Su-zhi~2,GAO Yu-qi~1,MU Xin-bin~2,SHI Quan-gui~2,HE Gui-qiang~2,SUN Ze-ping~2,HONG Yong~2,LI Xuan~2,ZHENG Jian-bao~2,WANG Hong-bin~2,HUANG Wen-chao~2,SAN Wei~2 1.Department of High Altitude Military Medicines,Third Military Medical University,Chongqing,400038;2.General Hospital of Tibet Military Command,Lhasa,850003;;Effects of polyclonal antierythropoietin antibody on stimulating colony-forming unit-erythropoiesis[J];西南国防医药;2006-01
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