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《Medical Journal of National Defending Forces in Southwest China》 2016-01
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Effects of mannatide injection on nutritional status and immunological function of patients after operation on gastric carcinoma

Fang Congyou;Wang Yijun;The Third Department of Surgery, the Second People's Hospital of Neijiang City;Neijiang Medical School of Sichuan Province;  
Objective To investigate the effects of mannatide injection on the postoperative nutritional status and immunological function of patients with gastric carcinoma. Methods 64 cases of gastric cancer that received operation in the hospital were randomly divided into control group and observation group with 32 ones in each group. The control group received chemotherapy with gemcitabine and capecitabine combined with enteral nutrition support after the operation. The observation group received intravenous drip with mannatide based on the same treatment as the control group. Observation was made in the changes of serum tumor markers,nutritional status, and immune function index levels between the two groups. Results Two weeks after the operation, the serum CA-153, CEA, and CA-199 in the observation group were significantly lower than those in the control group(P 0.01). The nutritional status indicators such as ALB, PA, and TP and immune function indexes like IgA, IgM, IgG, CD4+, and CD8+levels in the observation group were significantly higher than those in the control group(P 0.01). Conclusion Mannatide injection for the treatment on patients with gastric cancer after operation can inhibit tumor cell synthesis, decrease the recurrence rate, improve the nutrition status,and enhance the immunological ability.
【CateGory Index】: R735.2
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