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《Medical Journal of National Defending Forces in Southwest China》 2016-04
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Treatment of metaphase and advanced HCC by endostatin combined with TACE

Chen Tao;Zhang Tao;Zhu Yajie;Li Dong;Li Yan;Liu Mingchang;Cheng Peng;Center for Diagnosis and Treatment of Tumor,General Hospital of Chengdu Military Command;  
Objective To explore the curative effects of endostatin combined with TACE on metaphase and advanced HCC.Methods Seventy cases of metaphase or advanced HCC were selected and divided into observation group(34 cases) and control group(36 cases) according to the treatment intention. The patients in the control group were given TACE only, while those in the observation group were given TACE combined with endostatin. The curative effects and adverse reactions were observed and compared between the two groups after the treatment. Results The disease control rate of the observation group was 85.3% which was significantly higher than that of the control group(63.9%)(P 0.05). After the treatment, the levels of AFP in the two groups significantly decreased(P 0.05), while the decreasing extent of the observation group was larger than that of the control group. The VEGF levels of the control group increased, while those of the observation group decreased after the treatment. The difference was significant(P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P 0.05).Conclusion TACE combined with endostatin can improve the curative effects on metaphase and advanced HCC without additional side effects, which is worthwhile to be further studied.
【Fund】: 中华国际医学交流基金项目(CIMF-F-H001-210)
【CateGory Index】: R735.7
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