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《Medical Journal of National Defending Forces in Southwest China》 2016-04
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Effects of dexmedetomidine combined with dezocine on hemodynamics and agitation of patients receiving general anesthesia

Wang Yongxiang;Cao Jinfeng;Department of Anesthesiology, Hospital 215 of Nuclear Industry;  
Objective To investigate the effects of dexmedetomidine combined with dezocine on the hemodynamics and agitation of patients receiving general anesthesia during gastrointestinal surgery. Methods 120 cases receiving general anesthesia during gastrointestinal surgery between January 2013 and September 2015 were chosen as research objects and randomly divided into group A, B, and C. Group A was given continuous micro pump injection with 0.4 μg/(kg·h) dexmedetomidine; group B was given 0.1mg/kg dezocine; group C was given the same dosage of dexmedetomidine and dezocine. Comparison was made in the hemodynamic indexes before the anesthetic(T0), at the time of extubation(T1), 5 min after tracheal extubation(T2), and 10 min after tracheal extubation(T3), and the extubation time, respiratory recovery time, awakening time, and agitation during the awakening period among the three groups. Results In the contrast within groups, compared with the SBP, DBP, MAP, and HR at T0, those of the three groups at T1 had no significant changes(P 0.05); those of group A and B at T2 and T3 significantly increased(P 0.05), while those of group C still had no significant changes(P 0.05). In the contrast among the groups, the differences in the SBP, DBP, MAP, and HR at T0 and T1 were not significant(P 0.05); those indexes of group A and B at T2 and T3 were significantly higher than those of group C(P 0.05), while the differences between group A and B were not significant(P 0.05). There were no significant differences in the extubation time, respiratory recovery time, and awakening time among the three groups(P 0.05). The Ramsay scores during the awakening period of group A and B were signifncantly lower than those of group C, while the incidence of agitation during the awakening period of the former two groups was significantly higher than that in the latter one(P 0.05). Conclusion The dexmedetomidine combined with dezocine can maintain hemodynamic stability during the anesthesia, decrease the degree and incidence of agitation during the awakening period, which is worthy of clinical promotion.
【CateGory Index】: R614.2
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