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《Medical Journal of National Defending Forces in Southwest China》 2016-09
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Expression level of ISG15 in breast cancer and its clinical significance

Wang Junwu;Xia Tian;Wu Xiaoting;Gastrointestinal Surgery Center,West China Hospital of Sichuan University;Department of Pathology,Hospital 452 of PLA;  
Objective To study the expression level of ISG15 in breast cancer,its correlation with clinical pathology and its clinical significance.Methods A total of 105 breast cancer tissue samples from excision were collected to detect the expression level of ISG15 through Envision IHC and conduct tissue scoring to analyze the correlation between the expression level of ISG15 and the clinical pathological parameters in patients.Results The expression levels of ISG15 in breast cancer tissues were high,and the IHC scores were 5.17 ±1.07; the scores in the Basal-like "triple negative" breast cancer among the four subtypes of pathology genetics breast cancer were the highest 6.20 ±1.13(P 0.05); the expression levels of ISG15 were positively correlated with TNM neoplasm staging and negatively correlative with the expression levels of the cancer suppressor gene HER-2(P 0.05).The expression levels of ISG15 were not significantly related to the ages of patients,menopause or not,lymphatic metastasis,tumor size,and the expression levels of ER and PR(P 0.05).Conclusion Theexpression levels of ISG15 are related to the TNM staging of breast cancer tissues and the cancer suppressor gene HER-2,and have certain clinical value in the severity evaluation and prognosis of breast cancer.
【CateGory Index】: R737.9
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiaoting,JIANG Apei,FENG Qing School of Public Health,Nanjing Medical University,Nanjing 210029,China;Ubiquitin-like protein ISG15 and its modification system in tumor[J];生命的化学;2011-05
2 WAN Xin-Xing1),ZHANG Dian-Zheng1),2),CHEN Han-Chun1) (1) Department of Biochemistry,School of Biological Science and Technology,Central South University,Changsha 410013,China;2) Department of Biochemistry /Molecular Biology and Center for Chronic Disorders of Aging,Philadelphia College of Osteopathic Medicine,Philadelphia,PA 19131,USA);The Functions of ISG15 Ubiquitin-like Modifier and Its Modifier Enzymes[J];中国生物化学与分子生物学报;2010-04
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Wang Junwu;Xia Tian;Wu Xiaoting;Gastrointestinal Surgery Center,West China Hospital of Sichuan University;Department of Pathology,Hospital 452 of PLA;;Expression level of ISG15 in breast cancer and its clinical significance[J];西南国防医药;2016-09
2 ZHANG Dong-jie,LIU Di,BIE Shu,SUN Hong-tao,WANG Liang,WANG Wen-tao,HE Xin-miao (Heilongjiang Academy of Agricultural Sciences,Harbin 150086,China);Gene Expression Analysis upon Cold Induced by Affymetrix Pig Chip[J];畜牧兽医学报;2011-12
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