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《Medical Journal of National Defending Forces in Southwest China》 2016-09
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Value of combined detection of CA125 and CA199 in auxiliary diagnosis of endometrial carcinoma

Liu Xiaoliang;Ren Jiankang;Department of Laboratory,Shangluo Central Hospital;Department of Laboratory,Shaanxi Provincial People's Hospital;  
Objective To explore the value and clinical significance of carbohydrate antigen 125(CA125) and CA199 in the auxiliary diagnosis of endometrial carcinoma.Methods The patients with endometrial carcinoma and patients with benign uterus lesions admitted to our hospital,and healthy people who underwent physical examination in our hospital from February 2013 to February 2015 were selected as an endometrial carcinoma group,a benign uterus lesions group,and a healthy control group(n=100,respectively) to detect the levels of CA125 and CA199 in the three groups.Results The level and positive rate of CA125 in endometrial carcinoma group were(219.6±71.5) U/ml and 69.0%,and(101.2±43.9) U/ml and 45.0% for of CA199.These indicators were higher than those in the other two groups(P 0.05).The levels and positive rate of CA125 and CA199 in benign uterus lesions group were much higher than those in the healthy control group(P 0.05).The levels of CA125 and CA199 increased along with tumor progression(P 0.05).The sensibility,specificity,PPV,NPV and accuracy of combined detection of CA125 and CA199 were81.0%,94.0%,87.1%,90.8% and 89.7%,which were higher than those in the detection of single item(P 0.05).Conclusion The detection of CA125 and CA199 is related to the diagnosis and staging of endometrial carcinoma to certain degree.The combined detection of CA125 and CA199 can improve the diagnostic efficiency of endometrial carcinoma.
【CateGory Index】: R737.33;R730.43
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